Control of acid-base and ammonia homeostasis by the liver

نویسنده

  • WINFRIED FELLENZ
چکیده

Apart from its role in ammonia elimination hepatic urea synthesis helps to maintain the acid-base homeostasis. To understand this sophisticated control mechanism a mathematical model was developed that includes the glutamine metabolism of the liver at its core. The model consists of sigmoid kinetic functions controlling the periportal production of ammonia by glutaminase (EC 3.5.1.2), the perivenous elimination of excess ammonia by glutamine synthetase (EC 6.3.1.2), and the carbonic anhydrase (EC 4.2.1.1) catalysed bicarbonate supply for urea synthesis. Key-Words: homeostasis, hepatocyte, metabolic control

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

2.3.8 Protein synthesis and degradation in the liver

136 Christensen HN, Kilberg M (1995) Hepatic amino acid transport primary to the urea cycle in regulation of biologic neutrality. Nutr Rev 53, 74–76. 137 Balboni E, Lehninger AL (1986) Entry and exit pathways of CO2 in rat liver mitochondria respiring in a bicarbonate buffer system. J Biol Chem 261, 3563–3570. 138 Curthoys NP, Watford M (1995) Regulation of glutaminase activity and glutamine me...

متن کامل

The Effects of Cholestasis and Cirrhosis on Gastric Acid and Pepsin Secretions in Rat: Involvement of Nitric Oxide

Objective(s) The liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. Cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. Some studies reported a gastric acid secretion reduction in cirrhotic subjects, wh...

متن کامل

Removal of air ammonia in a spray tower by dilute sulfuric acid solution

Introduction: Workplace air quality is a very important factor in community health and is measured by measuring and evaluating airborne contaminants. One of these airborne pollutants is ammonia gas. Spray towers are important components of air pollution control. The aim of this study was to investigate the effects of using diluted sulfuric acid solution on the efficiency of ammonia removal in a...

متن کامل

اثر تمرین استقامتی با و بدون مصرف عصاره مگنولیا بر سطوح استراحتی نسفاتین-1، گلیکوژن و TAC کبدی در موش‌های صحرایی نر

Background and Objective: Nesfatin-1 is a 82-amino acid peptide recently discovered in the brain which is derived from nucleobindin2 (NUCB), a protein that is highly conserved across mammalian species. The purpose of the present study was to investigate the effect of endurance training with and without Magnolia officinalis extract on resting level of liver nesfatin-1, glycogen and TAC in male r...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2004